Mechanisms and emerging strategies for irinotecan-induced diarrhea

S Xu, H Lan, C Huang, X Ge, J Zhu - European Journal of Pharmacology, 2024 - Elsevier
… for the prevention and treatment of delayed diarrhea. We … balance of intestinal absorption
to cause diarrhea. Moreover, … Clomiphene is such an orally activated carbon composed of …
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Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation

K Kailass, D Casalena, L Jenane… - Journal of medicinal …, 2024 - ACS Publications
… ) that has a lower intestinal absorption, thereby reducing the cytotoxicity experienced by the
… for controlling Irinotecan conversion in patients suffering from life-threatening diarrhea as a …
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Targeting Carboxylesterase 2 Activity for Predicting and Improving Response to Pancreatic Cancer Treatment

K Kailass - 2023 - search.proquest.com
… Irinotecan, a key chemotherapeutic drug, is activated by … biomarker of patient response to
irinotecan, whereby low activity of … and improving resistance to irinotecan-based therapies. To …
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